Lawrence Kennedy  

CDR, USN

(410) 293-6612

lkennedy@usna.edu

Degrees

  • B.S. Chemistry, USNA, 1992
  • Ph.D Chemistry, University of Memphis, 2012
    Thesis Title: Modulation of Keratinocyte Differentiation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
    and Epidermal Growth Factor

Current Reseach Projects

My research will focus on finding a suitable inhibitor of the human enzyme CYP1B1, a member of the cytochrome P450 super family of enzymes. This particular enzyme has been strongly linked to both breast and uterine cancer, particularly the more invasive types. Successfully inhibiting the activity of this enzyme may lead to improved methods of defeating breast and uterine cancer.

Publications

"2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Production of Reactive Oxygen Species Is An Essential Step in the Mechanism of Action to Accelerate Human Keratinocyte Differentiation," Kennedy LH, Sutter CH, Leon Carrion S, Tran QT, Bodreddigari S, Kensicki E, Mohney RP, Sutter TR, Toxicol Sci, 2013, 132(1), 235-249.

"EGFR regulation of epidermal barrier function," Tran QT, Kennedy LH, Leon Carrion S, Bodreddigari S, Goodwin SB, Sutter CH, Sutter TR.

Conference Presentations

L. Kennedy, C. Sutter, T. Sutter, 51st Annual Society of Toxicology Meeting, March 11-15, 2012.

Professional Affiliations and Offices

Member of the Society of Toxicology

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