Copper-Catalyzed Trifluoromethylation of Aryl Halides via Concurrent Tandem Catalysis

Midshipman Researcher(s): 1/C Claire Holmvik

Adviser(s): Professor Shirley Lin and Professor Amy MacArthur

Poster #14

The design of a microwave-assisted, concurrent tandem catalytic (CTC) methodology for the copper-catalyzed trifluoromethylation of aryl bromides and aryl chlorides is proposed. In the CTC methodology, aryl bromides and aryl chlorides are transformed into a more reactive aryl iodide before undergoing trifluoromethylation. Progress toward adapting published examples copper-catalyzed trifluoromethylation of aryl iodides to microwave conditions will be discussed. Experimental challenges, such as accurate quantification of product yields, are presented.

Full Size Chemistry #14