Synthesis and antimalarial
activity of 7-benzylamino-1-isoquinolinamines
E.; Hoffman, Marshall M.;
Bhattacharjee, Apurba K.; Gerena,
computer modeling has suggested that
should mediate antimalarial effects
by a mechanism distinct from that
employed by existing antimalarial
drugs. These compds. were prepd.
dihydrochloride) in seven synthetic
steps, via reductive amination of 1,7-isoquinolinediamine.
In vitro efficacy testing of the
novel compds. against Plasmodium
falciparum revealed them to be
potent antimalarial agents.