SC111 - Foundations of Chemistry I
SC112 - Foundations of Chemistry II
SC495/496 - Chemistry Research Project
SC431 - Microbial Chemistry
My students and I employ various molecular biology and biochemical methods to understand the mechanistic details of HIV type 1 (HIV-1) replication. HIV-1 is a retrovirus, that is a virus with an RNA genome which is converted to DNA and subsequently integrated into the genome of the infected cell. Camouflaging as a host gene, the retroviral genome is then replicated by the host cell’s transcriptional machinery. I am particularly interested in understanding how the newly synthesized, unspliced HIV-1 RNA genome is exported from the nucleus to the cytoplasm. This step is essential in HIV-1 replication and, thus, an ideal target for the development of novel therapeutics.
- O’Carroll IP, Thappeta Y, Fan L, Valdez-Ramirez E, Smith S, Wang Y-X, and Rein A. 2017. Contributions of individual domains to function of the HIV-1 Rev response element. Journal of Virology. In Press.
- O’Carroll IP and Rein A. 2015. Viral nucleic acids. Online Encyclopedia of Cell Biology.
- Fang X*, Wang J*, O’Carroll IP*, Mitchell M, Zuo X, Wang Y, Yu P, Rausch JW, Dyba MA, Kjems J, Schwieters CD, Seifert S, Winans R, Watts N, Stahl S, Wingfield P, Byrd RA, LeGrice S, Rein A, Wang Y-X. 2013. A unique topological structure of the HIV-1 Rev response element. Cell, 155(3):594-605. * Equal contribution by authors
- O’Carroll IP, Crist RM, Mirro J, Harvin D, Soheilian F, Kamata A, Nagashima K, and Rein A. 2013. Elements in HIV-1 Gag contributing to virus particle assembly. Virus Res. 171:341-345.
- O’Carroll IP, Crist RM, Mirro J, Harvin D, Soheilian F, Kamata A, Nagashima K, and Rein A. 2012. Functional Redundancy in HIV-1 Assembly. J. Virol. 86(23):12991-6