My research involves the application of computational chemistry techniques (a.k.a. “molecular modeling”) to problems in organic chemistry. The properties that are typically investigated involve structure, reactivity, conformation, solvation, binding affinity and the like.
I do work in physical and analytical electrochemistry. The project with major funding from the Navy is use of a new Scanning Electrochemical Microscope (SECM) to study novel anti-corrosion coatings. I am also beginning work to study the photochemistry of SPEEK polymer films and their potential use as a smart material.
Professor Campbell's research is concerned with state-to-state dynamics of chemical reactions involving atoms and simple molecules. Laser induced fluorescence and visible chemiluminescence detection of product states are coupled with photodissociation and molecular beam techniques to study the detailed dynamical properties of single reactive collisions.
Professor Cheek's research interests mostly involve the electrochemistry of organic compounds, including mechanistic studies and preparative aspects. Many studies are carried out using molten salts (or ionic liquids) systems as solvents. Room-temperature chloroaluminate molten salts are useful systems for these investigations because the Lewis acidity can be varied extensively simply by changing the melt composition. Such molten salt systems are very attractive for use in "green chemistry" (environmentally friendly) applications because they also have very low vapor pressures.
Professor Copper focuses on development of separation and detection methods for environmentally important molecules. Specifically, capillary electrophoretic and microchip separation methods are being developed to study environmental pollutants, explosives, and chemical warfare agent simulants. These projects are performed in conjunction with researchers at the Naval Research Laboratory, Washington, D.C.
Professor Ferrante's primary research interest lies in the use of spectroscopic techniques (IR, UV/Vis, ESR) for the elucidation of the geometric and electronic structures of unstable or highly reactive molecules, both organic and inorganic.
Explore a number of classes of organic molecules with the aim of producing easily-synthesized and novel compounds with potential as antimalarial therapeutics. This research involves the design, synthesis and then antimalarial testing of compounds. If you are interested in pursuing a project in such areas, do please get in touch!
Associate ProfessorPh.D., Johns Hopkins University
Synthesis of organic compounds for the study of neuroreceptors. Synthesis of radioactively labeled compounds for use in neuroreceptor imaging by PET (positron emission tomography) and SPECT (single photon emission tomography).
The Lin lab is interested in the synthesis of new materials through the development of novel reactions and the use of noncovalent interactions. For more information or if you are interested in becoming a member of the lab, please contact Professor Lin.
My research focuses on measuring the: 1) decline in nitroarene solubility due to the presence of salts (salting-out); 2) photolysis of nitroarenes in seawater; 3) enhancement in solubility of nitroarenes in surfactant solutions (micellar solubilization); and 4) physical properties of alternative fuels (biodiesel and Fischer Tropsch Fuels) such as density, surface tension, and interfacial tension with pure water and seawater systems.
My work focuses on the development of economical metal catalysts to improve the reactivity of compounds with very strong bonds, such as carbon-hydrogen and carbon-chlorine bonds, via concurrent tandem catalysis. The development of catalytic reactions that activate such strong bonds would give scientists access to a wider array of favorable starting materials for the production of fine chemicals, pharmaceuticals, fuels, and novel materials that could have important military applications.
Associate ProfessorPh.D., New Mexico State University
Current work focuses on the gas phase reaction kinetics of transition metal atoms with sulfur dioxide. Computational studies on transition metal/sulfur dioxide complexes are also performed, with the overall objective of determining the reaction mechanism of transition metal + sulfur dioxide reactions. The experimental work is carried out in the laser lab at USNA (chemistry department), and the Gaussian 03 suite of programs is used for the computational work.
Associate ProfessorPh.D., University of Missouri, Columbia
All multicellular animals produce enzymes that can alter the sequence of their own RNA molecules. The biological roles for such “RNA editing” include: correcting errors in mitochondrial DNA sequences; regulating cholesterol metabolism; and producing multiple forms of receptors for various neurotransmitters. I am interested in the biological roles for a family of enzymes called “Adenosine deaminases that act on RNA” or “ADARs”. These enzymes convert adenosine (A) to inosine (I) within double-stranded regions of RNA.
Assistant ProfessorPh.D., Virginia Polytechnic Institute and State University
My students and I employ various molecular biology and biochemical methods to understand the mechanistic details of HIV type 1 (HIV-1) replication. HIV-1 is a retrovirus, that is a virus with an RNA genome which is converted to DNA and subsequently integrated into the genome of the infected cell. Camouflaging as a host gene, the retroviral genome is then replicated by the host cell’s transcriptional machinery. I am particularly interested in understanding how the newly synthesized, unspliced HIV-1 RNA genome is exported from the nucleus to the cytoplasm. This step is essential in HIV-1 replication and, thus, an ideal target for the development of novel therapeutics.
My research focuses on ecology, especially the chemical mediation of animal-plant interactions. For example, I collaborate on a project that investigates the relative roles of plant genetics and chemistry on community and ecosystem processes, using hybrid cottonwood trees and their associated fauna. Other projects study plant chemical effects on herbivore physiology, possible effects of climate change on plant-animal interactions, and the variability of plant chemistry in nature. As part of this work, student projects can include significant amounts of natural products and analytical chemistry.
ProfessorPh.D., California Institute of Technology
Protein structure-function studies, using x-ray crystallographic and biochemical methods, are my research focus. I am determining the crystal structures of a series of mutants of Staphylococcal nuclease to probe the effects of inserting ionizable residues into the protein interior. Another project involves the isolation of proteins from psychrophilic bacteria, which live at near-freezing temperatures. These proteins will be studied to identify potential molecular adaptations to cold environments.
Characterization and application of elastomers, networks, coatings, and specialized polymeric systems. In collaboration with the Naval Research Laboratory and US Army, my work involves military applications of polymers as well as fundamental studies of polymer dynamics. Current projects include designing new polycarbonates for transparent armor applications, testing polymer coatings for blast protection on Humvees, enhancing elastomer performance using bimodal networks, and utilizing polymers to reduce drag on small Navy vessels. I am also interested in chemical education and laboratory development with a number of research students contributing to this work.
Associate ProfessorPh.D., California Institute of Technology
Dr. Siefert's research interests include atmospheric and aquatic chemistry. Dr. Siefert is interested in the chemical processing of atmospheric aerosols and their role as a source of chemical species (e.g., nutrients) to remote and coastal surface waters. Understanding these atmospheric sources is important since they can control ecological processes.
I currently have two main avenues of biochemical research: 1) understanding the interactions of small molecules, peptides, and nanoparticles with biological membranes, and 2) understanding how redox processes and metal-ion binding alter protein structure. Our lab uses a range of scientific methods, including bacterial cell culture and overexpression of recombinant bacteria, protein purification and characterization, and various spectroscopic and calorimetric techniques. I also have a parallel interest in the scientific imagery and concepts expressed in the poetry of Robert Frost.
The Sweet lab focuses on the chemistry and potential applications of microbial natural products, including biofuels from extremophilic algae, antibiotics from airborne microbes, and endotoxin molecules from arctic bacteria. Current work includes isolation and growth of organisms using the techniques of microbiology, discovery and structural determination with organic and analytical chemistry, and characterization of novel bioactive compounds using both biological and chemical techniques.
Development of nanoscale composites of polymers and bio-polymers with layered silicates and/or carbon nanotubes. Characterization of the physical, chemical, optical and electronic properties of these novel materials for potential applications in areas such as ballistic protection and low-observables (stealth). Work performed in collaboration with the Air Force Research Laboratory and the National Institute for Standards and Technology. Development of new ionic liquids for applications in high-energy density batteries. Characterization of the physical, electrochemical, and thermal properties of the ionic liquids. Work performed in collaboration with the Naval Research Laboratory.
Assistant ProfessorPh.D., West Virginia University
My research focuses on studying amyloidogenic proteins associated with neurodegenerative diseases such as Alzheimer's disease (AD), prion encephalopathies, etc. These diseases are commonly classified as protein-misfolding or amyloid diseases due to their association with the rearrangement of specific proteins to non-native conformations which can promote aggregation and deposition. I am especially interested in studying the physical/nanomechanical properties of lipid membranes, and how they modulate lipid-protein surface interactions and amyloid aggregation associated with neurodegenerative disease. The interaction of these proteins with various lipid surfaces has potential protein-misfolding disease implications. Various biophysical techniques are used in the lab ranging from colorimetric, biosensing assays to atomic force microscopy (AFM) to surface phenomena measured utilizing a Langmuir trough.